Not to be confused with Alice Cooper, the band where Vincent Furnier got his stage name from.
| Game | Song | Year | Album |
|---|---|---|---|
| SingStar '80s | Poison | 2007 | Trash |
| Grand Theft Auto IV: Episodes from Liberty City | Go to Hell | 2009 | Alice Cooper Goes to Hell |
| Rock Band 2 (DLC) | School's Out (Live) | 2009 | Classicks |
| I'm Eighteen (Live) | 2009 | Classicks | |
| Billion Dollar Babies (Live) | 2009 | Classicks | |
| Poison | 2009 | Trash | |
| Under My Wheels (Live) | 2009 | Classicks | |
| Vengeance is Mine | 2009 | Along Came A Spider | |
| Guitar Hero 5 (DLC) | Welcome to My Nightmare | 2010 | Welcome to My Nightmare |
| Guitar Hero: Warriors of Rock (DLC) | Poison | 2010 | Trash |
| We Sing Rock! | Poison | 2011 | Trash |
| Watch Dogs | Dangerous Tonight | 2014 | Hey Stoopid |
| Rocksmith 2014 (DLC) | Poison | 2018 | Trash |
| Rock Band 4 (DLC) | Feed My Frankenstein | 2019 | Hey Stoopid |
| Rocksmith+ | Why Trust You | 2022 | Trash |
| Lullaby | 2022 | The Last Temptation | |
| I Got a Line on You | 2022 | Trash | |
| I'm Your Gun | 2022 | Trash | |
| Billion Dollar Babies (Live) | 2022 | Classicks | |
| House of Fire | 2022 | Trash | |
| Spark in the Dark | 2022 | Trash | |
| Poison | 2022 | Trash | |
| No More Mr. Nice Guy (Live) | 2022 | Classicks |