MLB The Show 21 is a baseball video game by San Diego Studio and published by Sony Interactive Entertainment, based on Major League Baseball (MLB). It was released for the PlayStation 4 and PlayStation 5, as well as the Xbox One and Xbox Series X/S (a first for the franchise) which included it being on Xbox Game Pass at the release for the first time, with MLB Advanced Media co-publishing digital versions on the latter platforms. The sixteenth entry of the MLB: The Show franchise, it was released on April 20, 2021. San Diego Padres shortstop Fernando Tatís Jr. is featured as the cover star, and at age 22 is the youngest player to do so.
| Artist | Song | Other Games |
|---|---|---|
| 116 feat. Lacrae & Funky | La Fiesta | |
| Abstract Rude feat. Slug & Brother Ali | The Solution | |
| AC/DC | Shot in the Dark | Rock Band 4 (DLC) |
| Big K.R.I.T. | Pick Up the Pace | |
| Dillon Francis feat. BabyJake | You Do You | |
| Foo Fighters | Making a Fire | Rock Band 4 (DLC) |
| Foreign Air | Life Goes On | |
| Future Islands | For Sure | eFootball 2022 |
| Gorillaz feat. Beck | The Valley of the Pagans | Forza Horizon 5 |
| IDK | Santa Monica Blvd | NBA 2K22, Fortnite |
| Juvenile | Ha | |
| Michael Brun feat. Barbatuques | Destemperado | |
| Onyx | Slam | NBA 2K18 |
| Ozuna | El Oso Del Dinero | |
| Phil Augusta Jackson | Get It | |
| Relaye | Long Time Coming | |
| Royal Blood | Oblivion¹ | |
| Run the Jewels feat. Royal Blood | The Ground Below (Royal Jewels Mix)² | The Crew: Motorfest, Marvel's Spider-Man: Miles Morales |
| Songhoy Blues | Worry | |
| The Avalanches feat. Denzel Curry, Tricky & Sampa The Great | Take Care In Your Dreaming | |
| The Strokes | Brooklyn Bridge to Chorus | |
| Travis Barker & Wiz Khalifa | Drums Drums Drums | NBA 2K21 (Next-Gen) |
Notes[]
¹ Added to the soundtrack on April 30 as part of an update.
² Original version was featured in the cover reveal trailer for the game.