"Symphony of Destruction" is a 1992 song by Megadeth, from the album Countdown to Extinction, that has seen several uses in video games.
| Game | Year | Version |
|---|---|---|
| True Crime: Streets of LA | 2003 | original |
| Guitar Hero | 2005 | cover |
| WWE SmackDown! vs. Raw 2006 | 2005 | Steve Tushar Remix |
| FlatOut 2 | 2006 | original |
| Full Auto 2: Battlelines | 2006 | The Gristle Mix |
| NFL Street 3 | 2006 | Fear Factory Remix |
| Guitar Hero 5 (DLC) | 2010 | original |
| Operation Flashpoint: Red River | 2011 | original |
| Rock Band 3 (DLC) | 2012 | original |
| Fuser | 2020 | original |
| Beatstar | 2023 | original |