For info on members solo appearances: Method Man, Raekwon, Ghostface Killah, Ol' Dirty Bastard
| Game | Song | Year | Album |
|---|---|---|---|
| True Crime: New York City | Protect Ya Neck | 2005 | Enter the Wu-Tang (36 Chambers) |
| Saints Row | Mathematics feat. Wu-Tang Clan - Spot Lite | 2006 | The Problem |
| Skate 2 | Protect Ya Neck | 2008 | Enter the Wu-Tang (36 Chambers) |
| Def Jam Rapstar | C.R.E.A.M. | 2010 | Enter the Wu-Tang (36 Chambers) |
| Def Jam Rapstar (DLC) | Protect Ya Neck | 2010 | Enter the Wu-Tang (36 Chambers) |
| Watch Dogs | C.R.E.A.M. | 2014 | Enter the Wu-Tang (36 Chambers) |
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